Antimicrobial Myrtle Oil Nanoemulgel for Bacterial skin and Soft Tissue Infections

Interested medicinal essential oils had important role in combating various diseases, including skin and soft tissue diseases therefore the purpose of study to design, prepare and evaluate an antibacterial myrtle oil nanoemulgel and compare their efficacy against two bacterial strains, Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Nanoemulsions was prepare and pseudoternary phase diagram was constructed including three of structural components wthich are myrtle oil, polyoxyethylene (80) sorbitan monooleate and propylene glycol mixture 3:1 (w/w)% and double distilled water using the microwaves -based method. Six samples of nanoemulsion (N1-N6) were selected for characterization process and preparation nanoemulgel (G1- G6). Blank gel (G7) was also prepared to compare the antibacterial activity against G1- G6 formulations. The myrtle oil nanoemulgel (G1- G6) formulations were subjected for different evaluation. The one-way analysis of variance (ANOVA) was statistical test, where the level at (P≤0.05) was kept as significant value. The outcomes indicate that N1-N6 formulations has acceptable physicochemical features. The evaluation process for G1- G6 formulations indicate translucent, homogenous, with distinctive odor of essential oil represented by myrtle oil and no syneresis, slightly acidic pH, spreadability were (126.033 to 86.361g*cm/sec), non-Newtonian plastic flow, no skin irritation and obvious antimicrobial activity. The preparation of essential oil nanoemulsion and nanoemulgel formulations were exhibited suitable characterization, physical stability and antimicrobial activity that made it promise delivery system for treatment skin and soft tissue infection.