Identification and Biological activity of leaf extracts from Mallotus barbatus Muell. - Arg. in Lam Dong province, Vietnam

Leaf extracts of Mallotus barbatus Muell.-Arg., a plant species of the Euphorbiaceae family, were studied for the morphological and bioactive characteristics. The phylogenetic relationship was analyzed using DNA barcoding of the rbcl and ITS genes. Notably, ethyl acetate extract exhibits vigorous antibacterial, antifungal, antioxidant and cytotoxic activities, emphasizing its pharmaceutical potential. Furthermore, n-hexane and chloroform fractions showed promising inhibition of MDA-MB-231 breast cancer cell proliferation, with IC₅₀ values of 42.81±0.72µg/ml and 52.91±0.93µg/ml, respectively. These findings comprehensively understand the genetic basis and therapeutic potential of Mallotus barbatus Muell.-Arg., providing valuable insights for medical and pharmaceutical applications.