Enhancing Cyanocobalamin Stability through Polymer Cyclodextrins: A Comprehensive Review on light stability

Cyanocobalamin, an important form of vitamin B12, is significantly degraded when exposed to light, affecting its potency and effectiveness. In this review, we describe in detail the effectiveness of polymeric cyclodextrins as protectants for cyanocobalamin, with a particular focus on their role in enhancing photostability. This article summarizes recent advances and explains the mechanism by which polymeric cyclodextrins protect cyanocobalamin from photodegradation. We explained the structural properties of cyclodextrin, its encapsulation ability, and synergistic interaction with cyanocobalamin. Additionally, this review evaluates the different methods and analytical techniques used to assess photostability and provide insight into the practical implications for pharmaceutical and nutraceutical applications. By synthesizing current research results, this review will narrate how polymeric cyclodextrins serve as promising candidates for preserving the photosensitivity of cyanocobalamin and thereby demonstrate its sustained efficacy and efficacy in various formulations. It aims to provide a comprehensive understanding of what contributes to their applicability.