Research Journal of Pharmacy and Technology

SCOPUS
  • Year: 2025
  • Volume: 18
  • Issue: 3

Comparison of the phytoconstituents in Bauhinia purpurea L. bark extracts and evaluation of pancreatic lipase inhibition and antioxidant properties of Bauhinia purpurea L. bark ethanolic extract

1Department of Pharmacology, SRMC and RI, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai - 600116, Tamil Nadu, India

2Department of Pharmacognosy, Meenakshi Faculty of Pharmacy, Meenakshi Academy of Higher Education and Research, Mevalurkuppam - 602105, Tamil Nadu, India

Abstract

The present study primarily aimed to compare the qualitative phytochemical analysis in ethanol, petroleum ether and chloroform extracts of Bauhinia purpurea [BP]. The secondary objective of the study includes evaluation of pancreatic lipase inhibitory effects and antioxidant properties of Bauhinia purpurea ethanolic extract (BPE). Standard chemical techniques were used to determine the phytoconstituents of petroleum ether, chloroform and ethanolic extracts of BP. The in-vitro DPPH assay and pancreatic lipase inhibitory assays were performed to determine anti-obesity properties of BPE. The BPE exhibited dose-dependent antioxidant as well as pancreatic lipase inhibitory effects. The pancreatic lipase inhibitory effects were nearly comparable to positive control orlistat IC50. This could be due to its rich composition of flavonoids and phenols. Further the BPE may be evaluated in other experimental models to make it available of clinical use.

Keywords

Obesity, Pancreatic lipase, Stress