Development and In vitro evaluation of bioactive plant extracts emulgel a study against antimicrobial activity and its synergistic effect

The aim of the present research work focusses on development and in vitro evaluation of bioactive plant extract emulgel. A study against antimicrobial activity and its synergistic effect. Extraction was done by cold maceration, Soxhlet apparatus technique. Three formulations of O/W type of polyherbal emulgel were developed, namely F1, F2 and F3. The formulations were evaluated for physical characteristics like pH, spreadability and extrudability. Based on the results, F3 was found to be the best formulation with smooth texture, good spreadability and adequate extrudability which was subjected to antimicrobial activity. The plant extracts in combination showed better antibacterial activity at 25μg/ml and antifungal activity at 6.25μg/ml. The combined plant extracts showed better synergistic effect at 25μg/ml.