1Study of Program of Military Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Jawa Barat, Indonesia
2Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
3Department of Veterinary Clinic Reproduction and Pathology, Faculty of Veterinary, Universitas Pertanian Bogor, Bogor, Indonesia
4Department of Pediatric Dentistry, Faculty of Dentistry, Padjadjaran University, Bandung, Jawa Barat, Indonesia
5Department of Oral Maxillofacial Surgery, Faculty of Dentistry, Padjadjaran University, Bandung, Jawa Barat, Indonesia
This scoping review aims to investigate the impact of Intermittent Hypobaric Hypoxia (IHH) Therapy on the immune expression of Hypoxia-Inducible Factor-1 alpha (HIF-1α) and Vascular Endothelial Growth Factor (VEGF) in the context of osteogenesis of the mandibular bone. Through a systematic literature search of the PubMed, Scopus, and Web of Science databases, this review assessed the evidence linking IHH to increased expression of HIF-1α and VEGF, which play essential roles in osteogenesis and angiogenesis. Several studies showed that IHH exposure significantly increased the expression of HIF-1α and VEGF, which contributed to the stimulation of osteogenesis and angiogenesis in the mandibular bone, as seen from the histological and radiographic parameters improvement. The conclusions of this review support the concept that IHH can facilitate osteogenesis of the mandibular bone through mechanisms involving activation of HIF-1α and increased expression of VEGF.
Bone remodeling, Intermittent Hypobaric Hypoxia, HIF-1α, VEGF, Osteogenesis and angiogenesis
