An overview on structural and functional characterization of drug-excipient compatibility studies by FTIR, DSC, XRD and TGA

Drug compatibility is a crucial component of pharmaceutical development since it ensures the security and effectiveness of products made of many medications. Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), and Fourier Transform Infrared Spectroscopy (FTIR) are effective analytical methods used to examine medication compatibility. The ideas, approaches, and applications of FTIR, DSC, XRD, and TGA in characterizing drug compatibility are thoroughly examined in this review study and how they can be used together to examine drug interactions, crystalline changes, thermal behaviour, and degradation kinetics. Case studies that demonstrate how these methods have been successfully used in diverse pharmaceutical formulations are provided. This assists researchers and pharmaceutical scientists in creating secure and efficient drug combinations by providing a thorough perspective. The effectiveness and safety of pharmaceutical products are significantly influenced by the compatibility of medicinal components in therapeutic formulations. Different analytical methods, such as FTIR, DSC, XRD, and TGA are used to evaluate the compatibility of medication components. This review paper offers a thorough investigation of various methods and how they might be used to describe medication compatibility.