Department of Chemistry, Parul Institute of Applied Sciences, Parul University, Waghodia, Vadodara - 391760, Gujarat, India
Bis-indole analogs are synthesized by condensing aldehyde and indole and characterized by spectral analysis. The compounds were evaluated for antimicrobial activity against Enterobacter, Escherichia coli, Staphylococcus aureus, and Bacillus strains and showed promising results. Furthermore, an in silico ADME assessment of these drugs was performed. Only a small number of compounds were found to pass the projected toxicity examination, whereas all were found to pass the ADME evaluation. This research serves as a starting point for the discovery of new compounds with intriguing properties and minimal toxicity.
Antibacterial activity, ADME, Condensation, Bis-indole
