Preparation and Optimization of Nanostructured Curcumin Delivery Systems for Burn Wound Treatment

Nearly half a million people in the United States experience thermal burns every year, with around 40000 of them requiring hospitalization. Burn care has undergone major advancements in recent decades, which has resulted in the saving of lives. The severity of burns can lead to a condition known as burn shock, which is characterized by fluid and protein shifts, increased capillary permeability, and hypovolemia. Burns can be caused by either wet or dry sources. There is a growing interest in herbal-based medicine delivery systems because of its cost-effectiveness and environmental friendliness in comparison to conventional drugs. As a result of its antioxidant, anti-inflammatory, and antibacterial qualities, curcumin, which is derived from the Curcuma longa plant, is good for the healing of wounds. Nevertheless, its limited solubility restricts its application. To overcome this issue, we have developed polymeric nanoparticles that are loaded with curcumin (CuR-PNPs) to improve their solubility and biological efficiency. This study aimed to optimize CuR-PNPs for burn wound treatment and infection control. The optimization process employed statistical design, resulting in stable CuR-PNPs with controlled release kinetics and retained pharmacological activities. CuR-PNPs show promise as a versatile drug delivery system for pharmaceutical and biomedical applications, with potential for further clinical exploration. As a diverse drug delivery method for pharmaceutical and biological applications, CuR-PNPs have shown promise, and there is the possibility that they could be further investigated in clinical settings later on.