Exploring the potency of new Pyridopyrimidine derivatives: Synthesis and biological evaluation

Pyridopyrimidines are fused heterocyclic compounds that have gained significant attention in medicinal chemistry due to their diverse pharmacological activities. These compounds exhibit structural similarity to purines, making them valuable scaffolds for the development of bioactive molecules, particularly in anticancer drug discovery. New Substituted 2,4-diphenyl-12a,13-dihydro-5H-pyrido[2’,3’:4,5]pyrimido[2,1-b]quinazoline-5,7(12H)-dione (8a-h) derivatives were synthesized and evaluated for their anti-cancer activity. The corresponding pyrido [2, 3-d] pyrimidine derivatives (8a-h) were also synthesized from starting materials. Docking studies were performed and revealed that the synthesised compounds have similar binding modes against the prospective biological targets. The newly synthesized compounds have shown low to moderate reducing activity in the MTT assay.