Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2025
  • Volume: 18
  • Issue: 4

Correction of mPTP Dysfunction by some Polyphenol extracts

  • Author:
  • Nuriddin N. Soliyev1,*, Gulbakhor T. Abdullayeva2, Muzaffar I. Asrarov3, Gaybullo X. Lutpillaev4, Sakhiba D. Madrakhimova4, Rakhmatilla N. Rakhimov5, Sadbarkhon A. Mavlanova6, Ziyofat B. Khosilova7
  • Total Page Count: 6
  • Page Number: 1825 to 1830

1PhD Student of Namangan State University, Uzbekistan

2Professor of Tashkent State Technical University Named After Islam Karimov, DSc. Uzbekistan

3Professor of the Institute of Biophysics and Biochemistry at the National University of Uzbekistan, DSc. Uzbekistan

4PhD Student Institute of Bioorganic Chemistry Named after A.S. Sadikov, Uzbekistan, Tashkent

5PhD in Chemical Sciences, Senior Researcher, Institute of Bioorganic Chemistry Named After Acad, A.S. Sadykova ASRUz, Uzbekistan

6Head of the Department of Physiology of Namangan State University, Ph.D Uzbekistan

7Karshi State University, Department of Physiology, Uzbekistan

*Corresponding Author E-mail: nuriddinsoliyev499@gmail.com

Online Published on 24 July, 2025.

Abstract

In this article studied the corrective effect of polyphenol extracts PF-1, isolated from the Karelinia caspia plant and PF-4, isolated from the leaf of quince (Cydonia oblonga), growing in the Republic of Uzbekistan, on the permeability of mPTP in the liver of rats was studied. Studies have shown that polyphenol extracts PF-1 and PF-4(1μg/ml, 5μg/ml, 10μg/ml, 15μg/ml) induce mitochondrial mPTP in the presence of Ca2+ ions. The mPTP inhibitory activities of PF-1 and PF-4 polyphenol extracts ranged from 30% to <83%. The results obtained make it possible to create membrane-active drugs based on extracts of polyphenols PF-1 and PF-4.

Keywords

Mitochondrial membrane, Karelinia caspia, Cydonia Oblonga, mPTP, Extracts of polyphenols PF-1, PF-4