1PhD Student of Namangan State University, Uzbekistan
2Professor of Tashkent State Technical University Named After Islam Karimov, DSc. Uzbekistan
3Professor of the Institute of Biophysics and Biochemistry at the National University of Uzbekistan, DSc. Uzbekistan
4PhD Student Institute of Bioorganic Chemistry Named after A.S. Sadikov, Uzbekistan, Tashkent
5PhD in Chemical Sciences, Senior Researcher, Institute of Bioorganic Chemistry Named After Acad, A.S. Sadykova ASRUz, Uzbekistan
6Head of the Department of Physiology of Namangan State University, Ph.D Uzbekistan
7Karshi State University, Department of Physiology, Uzbekistan
*Corresponding Author E-mail: nuriddinsoliyev499@gmail.com
Online Published on 24 July, 2025.
In this article studied the corrective effect of polyphenol extracts PF-1, isolated from the Karelinia caspia plant and PF-4, isolated from the leaf of quince (Cydonia oblonga), growing in the Republic of Uzbekistan, on the permeability of mPTP in the liver of rats was studied. Studies have shown that polyphenol extracts PF-1 and PF-4(1μg/ml, 5μg/ml, 10μg/ml, 15μg/ml) induce mitochondrial mPTP in the presence of Ca2+ ions. The mPTP inhibitory activities of PF-1 and PF-4 polyphenol extracts ranged from 30% to <83%. The results obtained make it possible to create membrane-active drugs based on extracts of polyphenols PF-1 and PF-4.
Mitochondrial membrane, Karelinia caspia, Cydonia Oblonga, mPTP, Extracts of polyphenols PF-1, PF-4
