1Research Scholar, Department of Pharmaceutical Sciences, Central University of Haryana, Mahendragarh – 123031, Haryana, India
2Research Scholar, Raffles University, Department of Pharmaceutical Sciences, Japanese Zone, NH 8, Neemrana, Rajasthan – 301020
3Associate Professor, Geeta Institute of Pharmacy, Geeta University, Panipat - 132145, Haryana, India
4Associate Professor, School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh, Punjab - 147301, India
5Assistant Professor, Department of Pharmaceutical Sciences, Central University of Haryana, Jant-Pali, Mahendragarh – 123031, Haryana, India
Because of solubility issues, improving the bioavailability of drugs administered orally in solid medicament continue to be an obstacle for scientists dealing with the formulation design. A solid dosage form’s absorption of somewhat insoluble medications may be slowed down by their rate of disintegration. Therefore, scientists have a problem in improving the solubility aspects of the poorly soluble drugs utilizing solid dispersion approach. Solid dispersion methods have generated a lot of attention because they can speed up the dissolution aspects of the highly lipophilic medications and comparatively increase the bioavailability by lowering particle size of drug, enhancing wettability and creating amorphous particles. A class of solid products with at least two separate ingredients, often a hydrophobic medication or a hydrophilic inert carrier, are referred to as solid dispersions. Standard formulations like tablets or capsules can be replaced with solid dispersion made utilizing a number of processes, and it offers numerous benefits over them. This review summarizes and aims to give an insight about BCS classification, types of solid dispersion, their mechanism for solubility enhancement, carriers employed, methods of solid dispersion preparation, advantages, limitations, characterization and research work related to solid dispersions.
Solid Dispersion, Bioavailability, Carrier, Solubility, Lipophilic
