A Review on Formulation Development of Microencapsulation Based Drug Delivery System for Topical Application

Acne and hyperpigmentation are two most frequently occurring skin conditions that causes skin damage, inflammation or other skin conditions. Post-inflammatory hyperpigmentation is caused due to acne which can be treated topically. Thus, by considering future consequences of acne, a combined treatment for both diseases will be beneficial. The major barrier for topical administration is permeation through skin which can be overcome by using novel drug delivery techniques based on required particle size and compatibility of drugs. One such method of microencapsulation for betterment of drug delivery can be employed for topical application via transdermal route of skin. This article provides a basic overview of development of a combined formulation that can be used to treat both diseases in the context of consequences of each other. This article focuses on how the acne and hyperpigmentation are correlated and how the treatment and formulation can be developed using novel encapsulation technique along with their benefits. The aim of this article is to prepare a novel formulation which can prevent post-inflammatory hyperpigmentation caused due to acne by using microencapsulation as a method for improvement of drug penetration.