Secretome of Adipose-Derived Stem Cells with Aloe Vera Gel in Burn Injury Therapy: A Narrative Review

Large areas of organs, including the skin, which has the biggest surface area in the body, can sustain burn injuries. Certain burn injury therapies, such as skin grafting and wound excision, have drawbacks, including a delayed rate of wound healing, an increased risk of infection, discomfort, and the potential for hypertrophic scarring. By using adipose-derived stem cells (ADSCs) as the foundation for burn damage therapy, these drawbacks can be addressed. Recent research has shown that aloe vera gel and stem cell secretome can improve stem cell activity, particularly in wound healing. This review’s objective is to outline the advanced therapy’s synergistic potential when aloe vera gel and ADSC secretome are used to treat burn injuries. Growth factors (TGF-β1, PDGF, EGF, IGF-1, HGF, NGF, GM-CSF, MCP-1, CSF, VEGF, and FGF-2) and cytokines (pro-inflammatory and inflammatory) are among the bioactive compounds found in the secretome of ADSCs. These chemicals have a role in cell signaling, which mediates the therapeutic benefits of stem cell regeneration. The components of aloe vera—aloe, aloe-emodin, and glucomannan—have an anti-inflammatory and fibroblast growth factor-influencing action, which aids in wound healing and remodeling. Aloe vera gel and ADSC secretome have some synergistic promise as an advanced burn injury therapy that can speed wound healing while reducing the risk of infection and the development of hypertrophic scars. To precisely understand how ADSCs secretome work in conjunction with aloe vera gel for burn damage treatment, more investigation is necessary.