Formulation and Evaluation of Diclofenac Sodium Nanosuspension

The goal of the current study was to create and assess a nanosuspension of diclofenac sodium utilising a precipitation, acid-base neutralization process, and several polymers to improve the drug’s solubility and bioavailability. The nanosuspension formulation was clear, and further shaking revealed no sedimentation. The solubility of Diclofenac sodium in the nanosuspension formulations is greatest in methanol. All preformulation parameters were assessed, including the qualitative and pH-dependent solubility of the drug in various pH buffer solutions, as well as the organoleptic characterization of the drug sample, melting point, pH, identification of the drug samples using UV spectroscopy, and preparation of calibration curves. The objective of the present research work was to formulate and evaluate diclofenac sodium. The viscosity of the dispersion medium was more in formulation with HPMC than the other formulations with methyl cellulose. The particle size distribution of the nanosuspension was found to be good for HPMC stabilizer as compare to methyl cellulose. From this study it was concluded that Nanosuspension consist of HPMC as stabilizer showed better result as compare to nanosuspension consist of methyl cellulose as stabilizer.