Formulation, Development and Evaluation of Novel Gastroretentive Sustaine Release of Ciprofloxacin HCl Floating Matrix Tablet

Drugs that have limited absorption window in the gastrointestinal tract will have poor absorption. For these drugs, gastro-retentive drug delivery systems offer the advantage in prolonging the gastric emptying time. The aim of formulating floating tablets of ciprofloxacin was to prolong the gastric residence time after oral administration to accomplish the controlled release of drug. Ciprofloxacin, a broad-spectrum fluoroquinolone antibacterial agent and it is use in the treatment of bone and joint infections, diarrhoeal infection, lower respiratory tract infections, urinary tract infections and meningococcal prophylaxis. Floating tablets of ciprofloxacin were prepared by direct compression method using different grades (K-15 and K-4) of Hydroxyl Propyl Methyl Cellulose (HPMC) and PVP K30 using effervescent technique. Sodium bicarbonate was incorporated as a gas-generating agent. The effect of citric acid on drug release profile and floating assets was also examined. FTIR studies adapted that there was no incompatibility between the polymers and the drug. Tablet pre-formulation parameters were within the pharmacopoeias limit. Tablets were estimated by different parameters such as weight uniformity, content uniformity, thickness, hardness, in vitro release studies, resistance determination and kinetic analysis of dissolution data. Tablet showed ≤ 1min lag time, continuation of resistance for >12 h. The in-vitro drug release pattern of optimized ciprofloxacin floating tablets (F7) was fitted to different kinetic models which showed highest regression (r²=0.983) for first order kinetics. Ciprofloxacin floating tablets exhibited increased gastric residence time, there by improved bioavailability and therapeutic effect of the drug.