Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2025
  • Volume: 18
  • Issue: 6

The potency of Limosilactobacillus fermentum from fermented buffalo milk (Dadiah) sampled as novel antidiabetic through increased superoxide dismutase (SOD) expression

  • Author:
  • Rinita Amelia1,*, Faridah Mohd Said2, Farzana Yasmin2, Sandeep Poddar2, Harnavi Harun3, Yusti Siana4
  • Total Page Count: 6
  • Page Number: 2561 to 2566

1Head Department of Histology, Faculty of Medicine, Baiturrahmah University 49HM+QCR, Jl. Bypass, Aie Pacah, Kec. Koto Tangah, Kota Padang, Sumatera Barat, 25586, Indonesia

2Lincoln University College, Wisma Lincoln, 12-18, Jalan SS 6/12, 47301, Petaling Jaya, Selangor, Malaysia

3Faculty of Medicine, Andalas University, Limau Manis, Pauh, Padang City, West Sumatra, 25175, Indonesia

4Department of Nutrition, Medicine Faculty, Baiturrahmah University, 49HM+QCR, Jl. Bypass, Aie Pacah, Kec. Koto Tangah, Kota Padang, Sumatera Barat, 25586, Indonesia

*Corresponding Author E-mail: rinitaamelia@gmail.com

Online published on 7 Ocotber, 2025.

Abstract

Diabetes Mellitus (DM) is a global health crisis. Probiotic meals consistently acted as antioxidants by preventing lipid peroxidation and retaining antioxidant enzyme activity, such as Superoxide Dismutase (SOD). To analyse the effect of Probiotic L. fermentum from dadiah sampled as novel antidiabetes through increased antioxidant Mn-SOD expression in DN rat model.

This study is an experimental group designed with a post-test-only control group to analyse the effect of dadiah, LAB, and bacteriocin on alloxan-induced nephropathy diabetic rats. The groups are two control groups and five intervention groups for eight weeks. The production of the antioxidant manganese superoxide dismutase (Mn-SOD) was examined using Immunohistochemistry of kidney tissue and observe the level glucose blood serum.

According to the findings of the Kruskal-Wallis analysis, the p-value=0.014 (< 0.050). Thus, based on the results in blood glucose serum level by the Wallis scale test, the p-value=0.002 was obtained. Thus, it may be established that the average blood sugar levels vary significantly between treatments.

Probiotics in dadiah has been shown to boost Mn-SOD expression and decrease hyperglycemia in the Nephropathy Diabetes rats model.

Keywords

Hyperglycemia, Mn-SOD, Nephropathy Diabetes, Probiotic Dadiah