Design, synthesis, and neuroprotective effects of carboxylate and hydrazide derivatives against paraquat and rotenone induced Parkinson’s disease

The present work examined the neuroprotective and anti-Parkinsonian properties of derivatives of hydrazide and carboxylate. The synthesized compounds structures were confirmed by analysing their spectrum data. It was shown that both drugs worked well against the oxidative stress and catalepsy induced by Rotenone and Paraquat in mice. Various derivatives of Carboxylates and Hydrazide were synthesized and screened for potential anti-parkinsonian activity through molecular docking study and two derivatives i.e., SH-4 and SH-9 were selected for further in-vivo activity. The PQ model provided a suitable method for examining neuropsychiatric dysfunction, particularly changes in depressive and anxiety-like behavior. The synthesized compounds, SH-4 and SH-9 represented anti-parkinsonian activity comparable to standard drug.