Research Journal of Pharmacy and Technology

Hypercholesterolemia impacts blood vessel blockage and triggers atherosclerosis and coronary heart disease. The Tamarindus indica L (T. indica) contains relatively high antioxidant compounds, which are reported to have the potential to prevent hypercholesterolemia. To analyze the effect of ethanol extract of T. indica on reducing total Mus musculus cholesterol and histopathological changes of the liver and coronary arteries. The treatment group consisted of 24 Mus musculus, divided into three concentrations and positive and negative controls. Each group comprised four participants. This study investigated the antioxidant content using the DPPH method, analyzed total cholesterol levels with Autocheck Cholesterol, and evaluated changes in the liver and coronary arteries through H and E staining. IC₅₀T. indica has an antioxidant content of 10.45μg/mL. T. indica L had the effect of reducing total cholesterol, High-density lipoprotein (HDL), Low-density lipoprotein (LDL), and triglyceride, respectively, in the 35mg group (decreased 16%: increased 24%: decreased 30%; decreased 29%), 175mg (decreased 36%:increased 24%; decreased 32%; decreased 8% ), and a group of 350mg (decreased 40%: increased 28%; decreased 39%). Histopathologically, these three groups prevented fatty infiltration and degeneration in the liver and coronary arteries. T. indica, possessing a comparatively elevated concentration of antioxidants, can decrease overall blood cholesterol levels, LDL cholesterol, and triglycerides while concurrently increasing HDL cholesterol. It is evidenced by reduced degeneration and fat infiltration in the liver and heart when examined under microscopic analysis.