Osteoporosis and sympathetic nerve activity: A review

Ageing population progressively develops issues with skeletal health. One such major skeletal disorder is osteoporosis, that is sparked with imbalanced bone remodelling and is characterised by weak bones, altered microarchitecture along with increased fragility. These bone alterations commonly lead to vertebral or hip fractures in elderly. The physiological activities are regulated by sympathetic and parasympathetic nervous system. Evidence from experimental and clinical studies revealed significant role of sympathetic nervous system in bone homeostasis including osteoporosis. The bone remodelling isalso mediated by adrenergic neurons and its transmitters whichregulated by hypothalamus. The sympathetic signalling is also crucial for the osteoporosis development especially after menopause. In order to assess newer treatments for the disease, the potential role of sympathetic nervous system towards the development of osteoporosis is being investigated. The review outlines the evidences about significant role of sympathetic communication in bone remodelling with specific influence on osteoporosis.