Refined Liquisolid System for Enhancement of Dissolution rate Using Piroxicam

The purpose of this study was to explore refined liquisolid system as a significant method for dissolution enhancement of poorly water-soluble drugs. Refined liquid system was prepared using Piroxicam as a model drug by simply dissolving drug in a non-volatile liquid like DMSO and subsequently adsorbing the resulting drug solution onto the colloidal silica with large surface area and high liquid retention potential. The resulting product exhibited significant improvement in dissolution profile without compromising with the content uniformity. DSC of the formulation revealed existence of the drug in an amorphous state. A significant enhancement of dissolution profile was observed in case of adsorbate resulting from modified technique. Dissolution profile was much superior when compared to pure drug or conventional liquisolid system This improvement in dissolution profile can be attributed to the state of drug in solution form and that too in DMSO; water miscible solvent. Solution of Piroxicam in DMSO is adsorbed over enormous surface area of colloidal silica and hence is easily available for immediate release due to rapid miscibility of DMSO with gastrointestinal fluids. The resulting product also exhibited excellent content uniformity, steep improvement in dissolution profile, excellent content uniformity amalgamated with simplicity offers proposed technique a vast potential for commercial use.