ADMET properties, antioxidant activity and determination of Artocarpin level in hydroalcohol extract of Artocarpus lakoocha Buch. Ham leaves

Antioxidants are compounds that have the ability to impede the function of free radicals. The uncontrolled production of free radicals can cause several types of diseases that can result in death, such as diabetes, heart disease, and cancer. Antioxidants are produced internally (endogenous) or obtained outside the body, for example through food consumption (exogenous). Mobe leaves (Artocarpus lakoocha Buch. Ham) contain high levels of flavonoids and phenols, which can potentially be effective against free radicals. This research was conducted to determine the artocarpin content in the ethanol extract of Mobe leaves and test its antioxidant activity using various methods. Predictions of bioactivity, toxicity, and bio-pharmacokinetic profiles (absorption, distribution, metabolism, excretion, toxicity) of artocarpin compounds from this plant were also examined. The data on artocarpin levels in Mobe extract were 37.67±0.85mg/g. The limit of detection value is 0.34 µg/mL, and the limit of quantification value is 1.18µg/mL. The IC₅₀ values of the extracts were 144.26±0.02 (FRAP), 83.39 ± 0.07 (CUPRAC), 161.26±0.09 (Hydroxyl), and 191.46±0.13µg/mL (O-Phenanthroline). The predicted results of bioactivity, toxicity, and bio pharmacokinetic profiles also show great potential to be developed into natural medicines.