Exploring Pathway for the Identification of Potential Ligands against Focal Cortical Dysplasia

Focal cortical dysplasia (FCD) is neurodevelopmental disorder that is caused during the embryo development. In this disorder neurons in brain are not formed properly and it is deformed. FCD is malformation of cortical development and it is main cause of epilepsy it is also called as neuronal migration disorder. Recent research have shown that FCD is the main cause of epilepsy in children that can occur due to genetic factors or environmental factors. The current study was carried out to identify the potential drug, target protein was identified from the pathway analysis of Focal cortical dysplasia. Bioinformatics databases and tools were used for the screening of drug that shows binding with the target protein. Pathway analysis of tuberin protein by Reactome database and KEGG database. Homology modeling of tuberin protein was done using Swiss Model and result shows that Tuberin protein was modeled with 92.6% of residues in favored region (~98.0% expected) analyzed using Ramachandran plot. The molecular docking interaction was also studied by the Schrodinger software’s suite. The modeled protein structure of Tuberin protein was docked against Topiramate and Levetiracetam. The best interaction of Tuberin protein was identified with the Topiramate drug with the glide score -8.4kcal/mol. Therefore, the Topiramate was found potential drug as a potential inhibitor that shows interaction with tuberin protein have function in FCD.