Ameliorative effect of Sodium Cromoglycate in Isoniazid-Induced Hepatotoxicity in Mice

The Present study has been designed to evaluate the hepatoprotective potential of Sodium Cromoglycate (SCG) in INH hepatotoxic mice. Isoniazid (INH) (300mg/kg/day; orally) is administered to the mice orally for a period of 7 days, that has been reported to be a model of hepatotoxicity. Hepatotoxicity was assessed by measuring serum liver enzymes levels on 1^st, 4^th and 7^th day. Moreover, the oxidative stress was assessed by estimating TBARS and CAT. In addition to this inflammatory mediator TNF-α level was estimated on 8^th day. Further, the integrity of the liver tissue and mast cell degranulation was estimated by histopathological studies. Moreover, Liver index and comparison of hepatoprotective potential between SCG 50mg/kg, 100mg/kg and SIL 100mg/kg was also done. Treatment with SCG significantly restored the liver functioning by reducing the level of oxidative stress parameters, improving the level of biomarkers and attenuated mast cell degranulation.