Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2025
  • Volume: 18
  • Issue: 7

Effectiveness of Punica granatum Peel Extract as an Antifungal agent in the patients with Denture Stomatitis - A Randomized Double Blinded Clinical Trial

  • Author:
  • V. Mahalakshmi1,*, K. Jyothirmai2,**, Sudhakara Reddy3,***, Atla Srinivas Rao4,****, K.T. Sunil Kumar5,*****, M. Veerakumari6,******
  • Total Page Count: 5
  • Page Number: 3164 to 3168

1Former Postgraduate, Dept. of Oral Medicine and Radiology, Vishnu Dental College, Bhimavaram

2Professor and HOD, Dept. of Oral Medicine and Radiology, Vishnu Dental College, Bhimavaram

3Professor, Dept. of Oral Medicine and Radiology, Vishnu Dental College, Bhimavaram

4Professor and HOD, Dept. of Pharmacology, Sri Vishnu College of Pharmacy, Bhimavaram

5Associate Professor, Dept of Pharmacology, Sri Vishnu College of Pharmacy, Bhimavaram

6Reader, Dept. of Oral Medicine and Radiology, Vishnu Dental College, Bhimavaram

*Corresponding Author E-mail: vadladhi.mahalakshmi@gmail.com

**jyothirmaik@vdc.edu.in

***sudhakarareddyomr@gmail.com

****drasr@svcp.edu.in

*****sunil@svcp.edu.in

******veerakumari.m@vdc.edu.inph

Online Published on 08 October, 2025.

Abstract

Denture stomatitis is a form of oral candidiasis and is a very common inflammatory process on palatal and gingival mucosa which is in direct contact with the denture base. Punica granatum (Pomegranate) is the plant with medicinal and nutritional benefit for which it is used in medicine for treating various diseases.

To evaluate the effectiveness of Punica granatum peel extract clinically and mycologically in patients with denture stomatitis and to compare clinically and mycologically, the effectiveness of Punica granatum with that of Miconazole.

After obtaining informed consent a total of 50 patients diagnosed with denture stomatitis were selected. Each group consisted of 25 patients, and they were split into two at random. Group A received Punica granatum gel and Group B received Miconazole Daktarin® gel oral.

The results revealed significant difference in the erythematous area, number of petechiae and colony forming units within the study and control groups.

Punica granatum can be used as an alternative topical antifungal agent.

Keywords

Punica granatum peel, Denture stomatitis, Candida albicans, Miconazole 2%, Herbal formulation