Association between Forced Vital Capacity and Neutrophil to Lymphocyte Ratio in Type 2 Diabetes Mellitus

To study the association between forced vital capacity and neutrophil to lymphocyte ratio in type 2 diabetes mellitus.

To measure FVC in T2DM patients. To assess the Neutrophil to Lymphocyte ratio in T2DM patients. To determine the correlation between FVC and NLR in T2DM patients.

A Cross-sectional study was done on 90 type 2 diabetes mellitus patients. Inclusion criteria include Subjects who fit into the diagnostic criteria of Type 2 diabetes mellitus and a known case of diabetes mellitus within 10 years of duration on regular treatment, Age – 30-50yrs, Both gender and Healthy volunteers. Exclusion criteria include Age > 50yrs, H/O acute or chronic respiratory disease, H/O acute or chronic cardiorespiratory disease, Smoker, H/O tobacco chewing, H/O hypertension, BMI > 30, Pregnancy, H/O spinal or thoracic cage deformity, Past H/O abdominal or thoracic surgery, H/O connective tissue disorders, H/O cancer and H/O Neuromuscular disease. Complete blood count was done to assess neutrophil to lymphocyte ratio. PFT was done to measure FVC. The correlation between FVC and NLR was done.

A negative correlation was found between FVC and NLR in diabetic participants which was statistically significant.

The present study shows that as NLR increases, the forced vital capacity also decreases in T2DM. Hence, NLR along with FVC can be assessed during routine follow up of diabetic patients for early diagnosis of lung function abnormality in T2DM.