1Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, Malaysia – 56000
2Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Chennai - 600048, India
*Corresponding Author E-mail: venkatalakshmi@crescent.education
Online Published on 08 October, 2025.
The burgeoning field of protein engineering has paved the way for innovative developments in the realm of therapeutics. With an increasing understanding of the intricate structure-function relationships of proteins, scientists have harnessed advanced techniques to tailor protein properties, ultimately enhancing their efficacy and specificity in therapeutic applications which shows significant evolution in protein based treatment. This article comprehensively overviews of the recent advancements in protein engineering techniques and their impact on the development of novel therapeutics. Key topics covered include rational design strategies, directed evolution methodologies, and computational modeling approaches, elucidating how these techniques have enabled the precise manipulation of protein structures to achieve desired functional attributes. Additionally, the article highlights notable examples of engineered proteins that have exhibited promising results in preclinical and clinical settings, underscoring the transformative potential of these strategies in addressing challenging diseases and disorders. Thus, this article seeks to elucidate the potential of protein engineering in addressing intricate medical obstacles and promoting the progress of personalized and precision medicine. By shedding light on the latest trends and breakthroughs in protein engineering, this article aims to provide a valuable resource for researchers and professionals in the field, facilitating the continued progress and application of these advanced techniques in therapeutic biochemistry and biotechnology.
Protein engineering, Therapeutics, Computational modelling