Formulation Development for ER Tablets of Furosemide with Statistical Optimization and Characterization by RSM Factorial approach

The aim of this research was to formulate extended-release Furosemide tablets using Polylacticcoglycolic acid (PLGA) and Hydroxy Propyl Methyl Cellulose (HPMC) polymers. The wet granulation method was employed in the preparation, and a 3² Response Surface Methodology (RSM) factorial design was utilized, yielding a total of nine formulations (F1 to F9). The formulations were then subjected to thorough evaluation, which included assessing their physical parameters such as weight variation, hardness, friability, and thickness, as well as drug content and in vitro release profiles. All formulations conformed to the standards set forth by the Pharmacopoeia. The in-vitro dissolution experiments were performed utilizing the USP dissolution apparatus type-II (paddle method). Analyzing the dissolution profiles, formulation F1 emerged as the most optimal, showing the best extended-release profile.