1Department of Pharmaceutical Sciences, Faculty of Health Sciences, Marwadi University, Rajkot - Morbi Highway, Rajkot, Gujarat, India - 360 003
2C.K. Pithawalla Institute of Pharmaceutical Science and Research, Surat, Gujarat, India - 395 007
We designed and synthesized newer heterocyclic compounds with 1, 3, 4-thiadiazole, pyrimidine, and 1, 3, 4 - oxadiazole, with aimed to develop Histone Deacetylase (HDAC) inhibitors. The 1, 3, 4 - oxadiazole nucleus known for its diverse pharmacological properties and incorporating the thiadiazole and pyrimidine groups. The progress of synthesis was monitored using Thin Layer Chromatography (TLC). Further products were confirmed by IR, Mass spectra, melting point, IR and 1H-NMR. A molecular docking study indicated that synthesized compounds have great HDAC inhibitory activity. The biological evaluation of one derivative, compound VIII (a) was performed by the MTT assay, revealed notable anti-cancer activity. These findings suggest that the novel 1, 3, 4 - oxadiazole compounds could serve as promising candidates for futuristic development of anti-cancer agents.
Anticancer, Docking, 1, 3, 4-Oxadiazole analogues, Histone Deacetylase inhibitor, MTT assay
