Design and Evaluation of Furan Incorporated 1,5-benzodiazepine Targeting M5-T4L Receptor as Antidepressant

Depression is a frequent mental illness that can alter a person’s social and psychological behaviour by raising or lowering their mood. An estimated 700,000 deaths annually are attributed to depression, making it the fourth leading cause of suicide death for people between the ages of 15 and 29. Depression continues to be a significant worldwide health burden despite improvements in knowledge and treatment. Nowadays, antidepressant medications, surgery, and lifestyle changes are used to treat depression. Antidepressant medications, however, have the potential to have negative effects and may not work for certain depressed individuals. Research is now being conducted to find novel drugs and therapies for depression. Ten compounds were synthesized in this study based on two different ring configurations, and their in silico activity was evaluated (PDB ID: 6OL9). Targeting the M5-T4L receptor was the goal, with imipramine as the reference drug. According to the results, the ten newly developed compounds had much higher docking scores than the typical medication. These substances also showed a high propensity for binding and hydrophobic interaction.