Design, Synthesis of Novel Pyrazole Derivatives Bearing P-Amino benzene Sulfonyl Chloride Moiety with Anti-Inflammatory Activity and Exhibit Inhibitory effects against p38α MAP Kinase

In recent years, numerous pyrazole derivatives have been identified in scientific literature as potent anti-inflammatory agents. Among these, pyrazolyl sulfonamides and pyrazolyl derivatives of urea have demonstrated significant anti-inflammatory properties and the ability to inhibit p38α MAP kinase. This study aimed to determine the structures of these compounds using spectral data and evaluate their anti-inflammatory activity through in vitro assays. The anti-denaturation assay using bovine serum albumin (BSA) and the p38α MAP kinase assay were employed to screen the compounds for anti-inflammatory potential. Compounds that exhibited promising results in these initial assessments were further evaluated for their ability to reduce inflammation, induce ulcers, cause lipid damage, and suppress TNF-α. The findings highlight the therapeutic potential of these pyrazole derivatives in the treatment of inflammatory diseases and provide a basis for further development of novel anti-inflammatory agents.