Bioactivity Ethanol Extract of Songga Wood (Strychnos ligustrina): Antibacterial, Antifungal and Hepatoprotector

Songga wood (Strychnos ligustrina) is one of the plants that has the potential to be developed as a traditional medicine. Empirically, songga wood is a medicinal plant that has long been known and used by the people of West Nusa Tenggara to treat various diseases such as malaria, antioxidants, anti-inflammatory, treating wounds, and antimicrobial. The purpose of this study was to determine the antibacterial, antifungal, and hepatoprotective activities of ethanol extract of songga wood on Alkalin fosfatase (ALP) and bilirubin levels induced by carbon tetrachloride (CCL4). Antibacterial activity (Staphylococcus aureus, Escherichia coli) and antifungal (C. albicans) with 4 concentrations, namely, 0.125, 0.25, 0.5, and 1% by microdilution, while hepatoprotector activity is measured by bilirubin and ALP parameters invivo with 6 treatment groups, namely normal control, negative control (Na-CMC), positive control (cavicur 20 mg), and ethanol extract test group doses of 26, 52 and 104 mg/kgBW. The results showed the highest antibacterial and antifungal inhibitory activity at 1%, namely Staphylococcus aereus 84.63%, Escherichia coli 87%, and Candida albicans 84.93%. Hepaprotector activity at doses of 26, 52, and 104mg/kgBW showed ALP levels of 170.2, 153.7, and 118.7U/L, respectively. Furthermore, bilirubin levels were 1.8, 1.7, and 1.5mg/dl, respectively. The study can conclude that the ethanol extract of songga wood has antibacterial, antifungal, and hepatoprotective activities (P<0.05). This study is a reference in the discovery of new drugs sourced from natural materials.