The Central Composite Design Approach in the Formulation and Optimization of Domperidone Floating Tablets

The existing effort was planned to formulate floating tablets of domperidone employing a central composite design. The central composite design was used to analyse the systematic consideration of input and output factors and to generate design space. The direct compression method was utilized to create the domperidone floating tablets. Drug excipient compatibility studies were performed through FT-IR and DSC analysis studies. The concentration of polymers such as HPMC K4M, Pectin and PVP K25 were selected as independent variables. Floating lag time, Total floating time and percentage drug release were selected as dependent variables. It was discovered that the model was non-linear and that the curvature effect was substantial. Therefore, the central composite design was opted. Studies using FT-IR showed that there isn’t much of an interaction between the medication and the excipients. DSC experiments showed that the drug and excipient were compatible because the drug’s melting point (238°C–241°C) did not significantly alter when it was blended with the excipients. The precompression parameters of the prepared formulations showed good flow properties. The evaluation of post-compression parameters indicated that all the prepared formulations are within the specified limits. The floating lag time of the prepared formulation was found to be less than 360 seconds and a total floating time of more than 24 hrs. The Percentage of drug release of all formulations was in the range of 72.93% to 98.26%. Batches in desired ranges were chosen using the resulting design space/contour plots. The outcomes revealed that preliminary design was used to further develop polymer obsessions. It was determined that the central composite arrangement would be used to formulate domperidone gastro retentive floating tablets with a lesser number of preliminaries and more outstanding elements.