Development of Analytical and Experimental In-vivo Model to Unveil the Pharmacodynamic and Pharmacokinetic Aspects of Extrapharmacopeial Drugs

The herbal drug industry faces a significant challenge due to the scarcity of classical drugs with proven efficacy and established clinical utility. This necessitates the exploration of alternative drugs, particularly Extrapharmacopeial drugs, which hold immense potential. Ayurvedic pharmacology’s fundamental principle, “nothing on earth is non-medicinal,” underscores the importance of investigating these drugs. This study focuses on Cocos nucifera Linn. (Coconut shell), a folklore drug with diverse utility but limited scientific documentation. We employed analytical and experimental in-vivo models to elucidate the pharmacodynamic and pharmacokinetic aspects of this Extrapharmacopeial drug. Our research included organoleptic evaluation, Rasa (taste) analysis, Veerya (potency) analysis, and Vipaka (pharmacokinetic) studies. This comprehensive approach can be applied to unlock the therapeutic potential of numerous undocumented natural plant resources, ultimately contributing to new drug development.