The therapeutic effects of Herbonanoceutical from Tamoenju Leaves (Hibiscus surattensis L.) Extract on Myocardial Infarction in Diabetic Rats

This study investigates the cardioprotective effects of herbonanoceutical from Hibiscus surattensis L. leaf extract (HSL) against isoproterenol-induced myocardial damage in diabetic animals. This study was an experimental study using thirty-three male Sprague Dawley rats which were randomly divided into five groups. Diabetes induction was carried out with streptozotocin 50 mg/kg BW and nicotinamide 120 mg/kg ip. On the seventh to fourteenth days, treatment was given according to the group with concurrent isoproterenol (85 mg/kg ip) administration on day 13 and 14. Diabetic mice with myocardial infarction showed altered injury markers, increased lipid peroxidation in the myocardium, and elevated glucose and liver enzymes. Moreover, increased pro-inflammatory markers and histological severity were observed. The results obtained indicate that the herbonanoceutical HSL has the potential as a glucose-lowering agent, especially at a dose of 50 mg/kg BW, and also exhibits cardioprotective potential as a protective agent against heart damage, as demonstrated by its ability to reduce heart biomarkers (CK, CK-MB, LDH, SGOT, SGPT) in disease conditions, approaching the levels seen in healthy controls. Based on these findings, the herbonanoceutical HSL appears to be a promising new target as an adjuvant therapy to treat complications of diabetes and other related conditions.