Effect of Polymer Concentrations on Buccal Film Delivery Systems for Ethoxy Curcumin Analogue (EAC)

Ethoxy Analogue of Curcumin (EAC) is a compound with various therapeutic benefits but suffers from low bioavailability due to poor water solubility and rapid metabolism. Buccal films, which swell up to 80% when hydrated by saliva, offer a solution to enhance EAC's solubility and absorption. This study evaluated the effect of different polymer concentrations in buccal films on EAC release, using solid dispersion and solvent casting methods. Polyethylene oxide (PEO) showed the best release profile compared to pectin and hyaluronic acid, with higher polymer concentrations reducing release rates. The findings underscore buccal films' potential to improve EAC bioavailability, with polymer concentration being key to optimizing release.