Effect of Vitex Agnus Hydro Alcoholic Extract and Anti Prolactin and Antigrowth Hormone Therapy on Serum Estrogen Level in MNU Induced Tumorigenic SD Rats

Breast cancer is the most common cancer among women globally. It is known that around two-third of patients diagnosed with breast cancers are categorized as hormone dependent cancer. Epidemiological and investigational supports allude that estrogen in the etiology of breast cancer. Most established risk factors for breast cancer in humans probably act through hormone-related pathways, and increased concentrations of circulating estrogens have been found to be strongly associated with increased risk for breast cancer in postmenopausal women. Objectives: The present study is designed to find out the effect of Vitex agnus castus, a herbal extract and anti-prolactin and antigrowth hormone therapy on serum estrogen level in N methyl nitrosurea (MNU) induced SD rats.

The rats were divided into 6 groups. Control group, Tumor induced group, hyper prolactemia group, cabergoline, octreotide alone and in combination followed by tumor induction and pre, post vitex angus treated group.

The study results showed significantly (p<0.001) elevated estrogen levels in tumour induced (II), hyperprolactinemia (III) IVA, IVB VA, VB,VI, compared to group I and on the other hand the pretreated plant extract showed a reduction in the estrogen level compared to post treated.

Vitex Agnus is a good therapeutic agent in the treatment of tumorigenesis and prior to the tumour induction gives more beneficial than the post treated