Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2026
  • Volume: 19
  • Issue: 1

Role of Amphiregulin Growth Factor, Progesterone Hormone with Prostaglandin on Successful Implantation in PCOS Women Undergoing ICSI

  • Author:
  • Amora M. Abou-El-Naga1,*, Saad S Al-Dujaily2, Ahmed Badawy3, Sura B. Sharafaldeen1,4
  • Total Page Count: 8
  • Published Online: May 29, 2026
  • Page Number: 382 to 389

1Zoology Department, Mansoura University, Egypt

2High Institute for Infertility Diagnosis and ART-Al-Nahrain University, Baghdad, Iraq

3Collage of Medicine, Mansoura University, Egypt

4The University of Mashreq, Baghdad, Iraq

*Corresponding Author E-mail: ss_mash_2022@yahoo.com

Online Published on 29 May, 2026.

Abstract

The growth and maturation of the follicles and oocytes are influenced by many reproductive hormones and growth factors which in turn interfere with the success of fertilization and conception. We assessed the serum and follicular fluid levels of Progesterone, Prostaglandin E2 hormones, and Amphiregulin Growth factor on the day of ova pick-up and embryo transfer using enzyme-linked immunosorbent assay (ELISA). The result showed highly significant differences were encountered between PCOS and non-PCOS groups, serum (P4, PGE2, AREG) on the day of ova pickup (OPU), follicular (P4, PGE2, AREG) on the day of ova pickup (OPU) and embryo transfer (ET), All these variables were significantly (P<0.001) higher in non- PCOS groups in comparison with PCOS group.

1. Women with PCOS had significantly less serum and follicular fluid amount of Progesterone, Prostaglandin, and Amphiregulin growth factor than non-Pcos 2. Amphiregulin can be used as a predictor for increasing the successful pregnancy rate in IVF or ICSI protocol 3. Very strong positive correlation between AREG, PGE2, and P4 in serum and follicular fluid

Keywords

Amphiregulin, PCOS, PGE2