Explore the Antidiabetic Potential of Sechium edule: Ethanol Extract's Impact on Apoptotic Markers Caspase-3, Caspase-8, Bcl-2, and Bcl-xL in Type II Diabetic Rats

Type 2 diabetes mellitus is highly associated with apoptosis The several causes of T2DM include insulin resistance caused by obesity, inadequate insulin synthesis, and loss of -cell mass owing to -cell death. The ratio of pro- and anti-apoptotic Bcl-2 proteins (Bad, Bid, Bik, and Bax) to apoptosis is mostly responsible for hyperglycemia-induced cell death. Sechium edule is pharmacologically recognized to lower blood glucose in rats.

To examine apoptosis parameters in rats with type II diabetes.

This study was divided into six groups: control, diabetic rats, positive control, treatment I (50 mg/kgbw extract), treatment II (100 mg/kgbw extract), and treatment III (mg/kgbw extract). All rats were sacrificed at the conclusion of the research, and their blood was collected for further analysis of caspase-3, caspase-8, Bcl-x, and Bcl-2.

Showed that pro apoptotic parameters such as caspase-3, caspase-8, and bcl-xl concentration were significantly reduced (p<0,05) in the group of treatment III compared to the level of pro apoptotic in diabetic rats, while anti apoptotic bcl-2 parameters were significantly increased (p<0,05) in the group of treatment III compared to diabetic rats.

We demonstrated that injection of STZ and administration of Sechium edule extract ethanol modulates apoptotic parameters. The ethanol extract of Sechium edule reduces pro-apoptosis characteristics. This plant has the potential to become a diabetic medication candidate.