*Corresponding Author E-mail: nagasamyvenkatesh@jssuni.edu.in
Surfactants and polymers stabilize the nanosized drug particles that make up nanocrystals, which have become a viable drug delivery technology. An extensive summary of recent advancements and research on nanocrystals for topical and transdermal medication administration is given in this thorough analysis. It discusses preparation, stabilization, and characterisation techniques as well as important elements influencing their capacity to pass through biological barriers like skin. The efficiency of several administration routes (transdermal, ocular, nasal, and pulmonary) in improving permeability and localizing the drug is also extensively analysed in this paper. Evaluation is also given to the development of nanocrystal formulations into pharmaceuticals and clinical studies. The final section of the essay discusses potential applications of nanocrystals in medicine delivery in the future.
Nanocrystals, Nanotechnology, Techniques of production of nanocrystals, Poorly water-soluble drugs, Bioavailability enhancement