Formulation and Development of Aloevera Gel containing Solid Dispersion of Fluconazole

Fluconazole is an antifungal medication that exhibits limited solubility and might cause severe adverse effects when used orally. An endeavour was undertaken to enhance solubility by the utilisation of the solid dispersion technique. Six formulations were created utilising the solvent evaporation method, with β-cyclodextrin and Polyvinyl pyrollidone (PVP) serving as carriers. The water solubility, and in-vitro release characteristics of all solid dispersions were assessed and compared. The optimised formulation (F-2) was subsequently added to aloevera gel. The prepared gel was assessed for several parameters including percentage yield, assay, pH, viscosity, spreadability, extrudability, release, in-vitro kinetics, and stability studies. The gel formulation was determined to have a pH of 6.1. The viscosity was measured to be 5882.82 centipoise (cp) and exhibited favourable spreadability and extrudability. The drug content of the optimal formulation reached 96.31%, accompanied by a drug release rate of 96.5%. Therefore, including a complex into a gel can be a promising approach to enhance the solubility and effectiveness of a poorly water-soluble medication, while also boosting its antifungal action.