Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2026
  • Volume: 19
  • Issue: 2

Synthesis, Characterization and Antimicrobial Studies of Mn(II) and Cr(III) Ion Metal Complexes with Alprazolam Drug

  • Author:
  • Chandra Kant Bhardwaj1,*, Sana Rafi2, Shailey Singhal3, Abhilasha Mishra4, Amar Nath5
  • Total Page Count: 5
  • Page Number: 589 to 593

1Department of Chemistry, Graphic Era Hill University, Dehradun, Uttarakhand, 248002, India

2Department of Geography, HNB Garhwal University, SRT Campus Tehri, Uttarakhand, India

3Applied Science Cluster, School of Advanced Engineering, UPES, Dehradun, Uttarakhand, 248007, India

4Department of Chemistry, Graphic Era (Deemed to be University), Dehradun, Uttarakhand, 248002, India

5Department of Mathematics, COER University, Roorkee, Uttarakhand, 247667, India

*Corresponding Author E-mail: drckb2012@gmail.com

Abstract

Alprazolam with a molar solution of metallic nitrate has reacted to generate the complexes of Mn (II) and Cr (III). The molar solution of metallic nitrate and ligand (AP) was mixed in a 1:1 ratio. The complex formation takes place at room temperature. “The complexes have the predicted formula [(L)M(NO3)2], [(L)M(NO3)3] where M = Mn (II) and Cr (III) and L = AP “[Alprazolam]”. Bidentate and tridentate metal complexes were observed to have "N (1)" and "N (4)" positions on the ligands. An elemental analysis of complexes restricted to their stoichiometry. In the study, AP (alprazolam) and its complexes were examined against selected bacteria and fungi for their antimicrobial properties. Metal complexes showed greater antimicrobial activity than alprazolam in the current study.

Keywords

Antimicrobial Studies, Ion Metal Complexes, Alprazolam