Anti-pyretic Effect of Modified Panchatikta Kashaya Varti In Wistar Albino Rats

Panchatikta Kashaya is a widely used formulation in clinical practice due to its efficacy in fever management. This study aimed to evaluate the Jwaraghna effect of Panchatikta Kashaya Varti in Wistar albino rats, following the Cakradatta Jwara Chikitsa reference. Since the Varti is a modified form of Panchatikta Kashaya, pre-clinical evaluation is essential before clinical trials to determine its efficacy. An experimental study on Wistar albino rats revealed that Panchatikta Kashaya Varti had a significant impact compared to standard and control groups. The drug's efficacy in reducing pyrexia is assessed by recording rectal temperatures in experimental animals. The modified form of Panchatikta Kashaya Varti is designed to bypass first-pass metabolism, enhancing absorption rates and bioavailability. Panchatikta Kashaya Varti demonstrated a quicker onset and sustained significant effectiveness over a longer duration, underscoring its potential therapeutic value. The study shows the potential therapeutic value of Panchatikta Kashaya Varti in a 1.9g prepared dose, suggesting its promising role as an antipyretic agent.