1Department of Zoology, Gauhati University, Guwahati, Assam-781014
2PG & Research Department of Zoology, B. Borooah College (Autonomous), Guwahati, Assam-781007, India
*Corresponding Author E-mail: barshasarma29@gmail.com
Manihot esculenta Crantz, widely used in traditional medicine, is rich in bioactive compounds with potential antidiabetic properties. This study evaluated the antidiabetic activity of its leaf extracts using in vitro and in vivo models.
Leaves were extracted with methanol. α-Amylase and α-glucosidase inhibition assays were conducted to assess in vitro antidiabetic activity. Streptozotocin-induced diabetic male albino mice were used for in vivo evaluation. Blood glucose and serum lipid profiles were measured using standard methods.
The methanolic leaf extract showed IC₅0 values of 0.367 mg/ml (α-amylase) and 0.351 mg/ml (α-glucosidase). In diabetic mice, the extract significantly reduced blood glucose and improved lipid profiles (except HDL) in a dose-dependent manner.
Manihot esculenta leaves exhibit significant antidiabetic activity, supporting their potential as a natural therapeutic or functional food for diabetes management. Further research is needed to isolate active compounds and explore mechanisms of action.
Acute toxicity, Antidiabetic, α-Amylase, α-Glucosidase, Manihot esculenta
