Antiulcer Activity of Curcuma amada Roxb. and Curcuma aeruginosa Roxb. Ethanol Extract in Rats Mode of Gastric Ulcer: Biochemical and Histological Analysis

Mango ginger (Curcuma amada Roxb.) and Black turmeric (Curcuma aeruginosa Roxb.) are species of Curcuma commonly used as raw materials in traditional herbal medicine (jamu). The curcumin and flavonoid content in these plants are suitable for treating inflammation-related diseases, including gastric ulcers. This research aimed to determine the potential of ethanol extracts from Mango ginger (ERTM) and Black turmeric (ERTI) in protecting against ethanol-induced gastric ulcers in rats. The animals were pre-treated with ERTM and ERTI for two weeks and induced with an ulcer using absolute ethanol. The extent of the extract's protective effect was evaluated based on the biochemical parameters of gastric fluid and histological analysis of the gastric organ. The data were compared to the gastric contents of rats without pre-treatment. The results showed that the effectiveness of ERTM and ERTI in protecting the gastric from ulcers was approximately equivalent to omeprazole as a standard drug. Ethanol extract of C. amada and C. aeruginosa showed potential as gastroprotective agents and could be developed as antiulcer herbal medicines.