In silico Exploration of Bioactive Phytoconstituents of Hedychium coronarium as Candidates against Diabetic Cataract

Hedychium coronarium, commonly known as white ginger lily or butterfly ginger, or Gulbakawali, is a perennial herbaceous plant belonging to the Zingiberaceae family. The rhizomes of H. coronarium are rich in essential oils, flavonoids, and phenolic compounds, which contribute to its significant anti-inflammatory effects. Studies have demonstrated that extracts from H. coronarium can inhibit the production of pro-inflammatory cytokines and enzymes, such as cyclooxygenase-2 (COX-2) and nitric oxide synthase (NOS). Despite the extensive body of literature highlighting the pharmacological potential of H. coronarium, a critical research gap exists in the domain of computational-oriented diabetic cataract studies. A thorough search across various scientific databases, including PubMed, Scopus, Web of Science, and Google Scholar, reveals a significant absence of comprehensive computational analyses specifically targeting the anti-diabetic cataract forming properties of H. coronarium and its bioactive compounds. The research emphasized on exploring the inhibitory perspectives of phytochemicals present in H. coronarium such as Pacovatin A (1), Hedychenone (2), Coronarin E (3), Isocoronarin-D (4), Benzoyl eugenol (5), Cryptomeridiol (6), Peroxycoronarin D (7), Hedychicoronarin (8), Camphene (9), Linalool (10), Carvacrol (11), Geraniol (12), Spathulenol (13), Terpinolene (14), and Borneol (15) by molecular docking approach using the Schrodinger software as anti-diabetic cataract agent by using insilico approaches with the help of published literature on downregulation of expression and combining this information in order to recognize drug target [PDB ID: 4JGF; Crystal Structure of the Cataract-Causing P23T gamma D-Crystallin Mutant; https://doi.org/10.2210/pdb4JGF/pdb]. The in silico studies revealed that the phytoconstituents successfully inhibited the target that is involved in progression of diabetic cataract.