The Effect of Solid Dispersions on the Solubility of Tamsulosin Hydrochloride in an Aqueous Medium

The solubility of a pharmaceutical substance is a key aspect of the physico-chemical parameters that determine the bioavailability profile in the development of a dosage form. Insufficient solubility of the substance slows down the absorption and release processes, reducing the concentration of the active substance and reducing the therapeutic effect. The «solid dispersion» method is an innovative solution for improving the pharmacokinetic parameters and therapeutic profile of the substance. Tamsulosin solid dispersions with polymers represent a promising direction in the development of new dosage forms with improved characteristics. Tamsulosin hydrochloride a selective α1-adrenergic receptor antagonist used for treating benign prostatic hyperplasia, serves as a model drug in this study due to its poor aqueous solubility. The development of tamsulosin solid dispersions with various polymers offers a promising approach to overcome solubility limitations and optimize drug delivery. The study involved a meticulous selection of polymer matrices aimed at optimizing drug solubility and dissolution kinetics. State-of-the-art analytical techniques were employed for comprehensive characterization of the developed systems, enabling detailed evaluation of their physicochemical properties. This approach demonstrates significant potential for developing innovative dosage forms with enhanced pharmacokinetic parameters. The technology is particularly relevant for BCS Class II drugs, where poor solubility represents the major limiting factor for therapeutic efficacy.