Anti-inflammatory and Analgesic activities of alcoholic leaves extract from Platycladus orientalis: An In-vivo Evaluation

The leaves of Platycladus orientalis have been widely used in Chinese traditional medicines as anti-tussive and expectorant. Scientific studies have also showed its anti-inflammatory activity in various cell- based and animal models. However, there is no evidence for anti- inflammatory and analgesic activities of P.orientalis leaves collected from Indian origin. Therefore, the objective of this study was to evaluate the antiinflammatory and analgesic potential of P.orientalis of Indian origin.

Carrageenan, dextran, formalin and histamine induced paw edemas was figured out for Anti-inflammatory activity. Analgesic activity was determined using acetic acid and formalin induced paw licking response in rats.

Phytochemical screening revealed that the extract contains many phytochemicals including alkaloids, tannins, carbohydrates, glycosides and flavonoids. The ethanol extract significantly suppressed the paw edema induced by carrageenan, dextran, histamine and formalin in a dose dependent manner. Analgesic activity and chronic anti-inflammatory activities were also exhibited by Ethanol extract.

The above research demonstrates that the antiinflammatory and analgesic activity of alcoholic extract of P.orieantalis leaves was inconsequential or unimportant. These results finding further could be used to find the mechanistic investigations.