Advancements in Enteric Coated Nanoparticles for Improving Bioavailability of Poorly Soluble Drugs: A Comprehensive Study

Enteric-coated nanoparticles represent a cutting-edge strategy to improve the bioavailability and therapeutic effectiveness of orally administered drugs. By shielding drugs from gastric degradation and enabling site- specific release in the intestine, these nanoparticles ensure controlled and efficient drug delivery. This review explores the pharmacokinetic benefits of enteric-coated nanoparticles, including enhanced solubility, improved intestinal permeability, and reduced first-pass metabolism. Their applications span diverse therapeutic areas, such as gastrointestinal disorders, peptide and protein drug delivery, nonsteroidal anti-inflammatory drugs (NSAIDs), and targeted antibiotic/probiotic therapies. Emerging trends in this field include the use of biodegradable polymer coatings, hybrid nanocarrier systems, and innovations in 3D printing and artificial intelligence-driven formulation design. Additionally, regulatory challenges and scale-up considerations are discussed to bridge the gap between research and clinical translation. As advancements continue, enteric-coated nanoparticles have the potential to transform oral drug delivery, improving patient adherence, optimizing therapeutic efficacy, and paving the way for future applications in personalized medicine.