An Overview on Preparation and Evaluation of Microparticulated Intra-Vaginal Gel

Vaginal drug delivery systems are traditionally used to deliver contraceptives and drugs to treat vaginal infections. However, vaginal drug delivery is not limited to these drugs as the vagina has promise as a site to topically deliver drugs which will be absorbed systemically because of the dense network of blood vessels in the vaginal wall. This is an advantage over other routes of transdermal and transmucosal drug delivery. In addition, vaginal drug delivery has an advantage over oral delivery because it avoids the hepato-gastrointestinal first-pass metabolism of drugs. This review article contains method of preparation and evaluation of microparticles. Selection of microparticles used for the preparation of intra-vaginal gel, and method of preparation and evaluation of intra-vaginal gel is also well explained in this review article.